N-containing compounds from seeds of Paganum harmala.
10.19540/j.cnki.cjcmm.20190118.009
- Author:
Xin FANG
1
;
Hai-Yang YU
1
;
Li-Feng HAN
1
;
Xu PANG
1
Author Information
1. Research Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine Tianjin 300193,China.
- Publication Type:Journal Article
- Keywords:
N-containing compound;
P. harmala;
Paganum;
Zygophyllaceae;
alkaloid
- MeSH:
Chromatography, High Pressure Liquid;
Nitrogen;
analysis;
Peganum;
chemistry;
Phytochemicals;
analysis;
Plant Extracts;
chemistry;
Seeds;
chemistry
- From:
China Journal of Chinese Materia Medica
2019;44(8):1601-1606
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the N-containing compounds in the seeds of Paganum harmala,fourteen compounds were finally isolated from the 95% Et OH extract of P. harmala seeds by using various chromatographic techniques including silica gel,MCI resin,and ODS column chromatography as well as the semi-preparative HPLC. Depending on spectroscopic techniques and comparison with the reported data in the literatures,the structures of all compounds were identified as N-[3-(2-amino-4-methoxyphenyl)-3-oxopropyl]acetamide(1),dehydroharmalacidine(2),harmalacidine(3),harmine N-oxide(4),harmine(5),tetrahydroharmine(6),demethylharmalacidine(7),harmol(8),tetrahydroharmol(9),harmindol β-D-glucopyranoside(10),tryptophyl β-D-glucopyranoside(11),pegamineβ-D-glucopyranoside(12),vasicol(13) and vasicinone(14). Among them,1 was a new compound,and 2 and 10 were obtained as natural products for the first time.
