Polyomavirus Induced Interstital Nephritis in Renal Allograft Recipient.
- Author:
Jang Il MOON
1
;
Hyun Joo JEONG
;
Soon Won HONG
;
Nam Sun CHO
;
Soon Il KIM
;
Yu Seun KIM
;
Kiil PARK
Author Information
1. Department of Surgery, Yonsei University, College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Renal allograft;
Polyomavirus;
Graft dysfunction;
Interstitial nephritis
- MeSH:
Allografts*;
Asymptomatic Infections;
Biopsy, Large-Core Needle;
Chromatin;
Constriction, Pathologic;
Creatinine;
Cyclosporine;
Cystitis;
Diagnosis;
Epithelial Cells;
Humans;
Immunosuppression;
Male;
Microscopy, Electron;
Nephritis*;
Nephritis, Interstitial;
Polyomavirus Infections;
Polyomavirus*;
Tacrolimus;
Transplants;
Ureter;
Virion
- From:The Journal of the Korean Society for Transplantation
1998;12(2):313-318
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report our experience of renal polyomavirus infection after renal allograft leading to graft dysfunction. A fourty seven-years-old male patient, has been on Tacrolimus based dual immunosuppression, showed graft dysfunction with rising serum creatinine at post-transplant day 140. His graft function had been good without any acute rejection episode. A tentative diagnosis of acute rejection was rendered and core needle biopsy was performed. Viral infection was initially suggested by the occurrence of markedly enlarged tubular epithelial cells containing large nuclei with smudgy chromatin pattern. Confirmatory diagnosis of human polyomavirus induced interstitial nephritis was obtained by electron microscopy, which showed viral particles in the nuclei of tubular epithelial cells. After Tacrolimus was converted to cyclosporine, renal function was stabilized. A review of the literature indicates that asymptomatic infection, ureteric stricture, and hemorrhagic cystitis are other possible manifestations of polyomavirus in the human urogenital tract. According to some prior reports, polyomavirus induced interstitial nephritis might be a cause of graft loss. But our patient has retained a stable graft function with a chnange of immunosuppression.
