Two New Scalaranes from a Korean Marine Sponge Spongia sp..
10.20307/nps.2015.21.4.289
- Author:
Inho YANG
1
;
Sang Jip NAM
;
Heonjoong KANG
Author Information
1. School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Korea. hjkang@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Scalarane;
Sesterpenoid;
Spongia sp.;
Korean sponge;
Marine natural product
- MeSH:
Porifera*;
Statistics as Topic
- From:Natural Product Sciences
2015;21(4):289-292
- CountryRepublic of Korea
- Language:English
-
Abstract:
Intensive chemical investigation of Korean marine sponge Spongia sp. has led to the isolation of two new scalaranes. The planar structures of the new compounds 1 and 2 were determined through 1D and 2D NMR spectral data analysis, while the relative stereochemistry of the compounds was determined based on the analysis of 1H-1H coupling constants and NOESY spectroscopic data. Compounds 1 and 2 did not display any significant biological activities on farnesoid X-activated receptor (FXR) in co-transfection assay.
