Expression and Clinical Significance of Peripheral Blood T cell JAK2/STAT3 mRNA in Chronic Idiopathic Thrombocytopenic Purpura.
10.7534/j.issn.1009-2137.2018.06.028
- Author:
Li SONG
1
;
Ning-Chao DU
2
;
Fu-Rong LI
3
;
Fang LIU
4
Author Information
1. Coilaboration Innovation Center of Transformation Medicine,Shenzhen People's Hospital，Shenzhen 518020, Guangdong Province, China.
2. Pharmacy School of Southern Medical University，Guangzhou, 510515，Guangdong Province, Chian.E-mail：dncnl2008@163.com.
3. Coilaboration Innovation Center of Transformation Medicine,Shenzhen People's Hospital，Shenzhen 518020, Guangdong Province, China.E-mail：frli62@163.com.
4. Department of Microbiological immunoplay，Zhanjiang 524023，Guangdong Province, China.
- Publication Type:Journal Article
- MeSH:
Chronic Disease;
Humans;
Janus Kinase 2;
genetics;
Purpura, Thrombocytopenic, Idiopathic;
RNA, Messenger;
STAT3 Transcription Factor;
genetics;
T-Lymphocytes
- From:
Journal of Experimental Hematology
2018;26(6):1746-1751
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To detect the expression of JAK2/STAT3 mRNA in peripheral blood T cells from the patients with chronic idiopathic thrombocytopenic purpura（CITP）, and to explore the relationship between JAK2/STAT3 mRNA and CITP.
METHODS:CITP group and healthy control group were set in this study, The JAK2/STAT3 mRNA expression level in peropheral blood T cells of 2 groups was detected with the RT-PCR and agarose gel electrophoresis.
RESULTS:JAK2 mRNA expression level in CITP group was significantly higher than that in control group（P<0.01）, the STAT3 mRNA expression level in CITP group was also higher than control group（P<0.01）, The JAK2/STAT3 mRNA expression level of CITP patiants increased obviously compared with control group.
CONCLUSION:The expression level of JAK2/STAT3 mRNA increases signficanlty in chronic ITP patients, which involves in pathogenesis of CITP.
