Identification of Phenotype and Genotype in One Case with Weak D blood group.
10.7534/j.issn.1009-2137.2018.06.036
- Author:
Hui-Ying XU
1
;
Rui WANG
2
;
Chun-Yan LIN
3
;
Shi-Fang YU
2
;
Chun-Hua LIU
4
;
Zhi-Hua TAO
1
;
Zhao-Ping LIAO
5
,
6
Author Information
1. Department of Laboratorial Medicine,The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China.
2. Department of Blood Transfusion, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China.
3. Department of Blood Transfusion, Wenling Hospital of Traditional Chinese Medicine, Wenling 317500, Zhejiang Province, China.
4. Department of Blood Transfusion, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province.
5. Department of Blood Transfusion, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province,China
6. E-mail：2514117@zju.edu.cn.
- Publication Type:Journal Article
- MeSH:
Alleles;
Asian Continental Ancestry Group;
Exons;
Genotype;
Humans;
Phenotype;
Rh-Hr Blood-Group System
- From:
Journal of Experimental Hematology
2018;26(6):1800-1803
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the phenotype and genotype of the weak D blood group in one case of Chinese Han people.
METHODS:Phenotype of blood sample was identified with serologic tests; PCR-SBT was applied for the analysis of genotype and RhD zygosity.
RESULTS:Both saline and gel card tests demonstrated this case to be dCcee, which was contrary to glass bead card result. Some of the RBC D epitopes were negative.c.1022T>A allele was identified with PCR-SBT and the zygosity analysis showed this case to be D/d.
CONCLUSION:RHD*1022 A is more suitable to be categorized as weak partial D other than weak D in a Chinese Han people.
