Advances of Researchs on Molecular Mechanisms of Mesenchymal Stem Cells and Their Exosomes in Angiogenesis--Review.
10.7534/j.issn.1009-2137.2018.06.047
- Author:
Jun-Qiu CHEN
1
;
Liang-Hu HUANG
2
Author Information
1. PLA Organ Transplantation Institute, Fuzhou General Hospital, Fuzhou 350025, Fujian Province, China.
2. Fujian Provincial Key Laboratory of Transplant Biology, Dongfang Hospital Affiliated to Xiamen University, Fuzhou 350025, Fujian Province, China E-mail: huanglianghu@xmu.edu.
- Publication Type:Journal Article
- MeSH:
Cell Differentiation;
Exosomes;
Humans;
Hypoxia-Inducible Factor 1, alpha Subunit;
Mesenchymal Stem Cells;
Neovascularization, Pathologic;
Neovascularization, Physiologic
- From:
Journal of Experimental Hematology
2018;26(6):1858-1862
- CountryChina
- Language:Chinese
-
Abstract:
Mesenchymal stem cells (MSC) have the potential of multi-directional differentiation, and can recruit endothelial cells, promote their proliferation, migration and angiogenesis, improve blood perfusion and oxygen suppliment, and repair damaged tissue. Exosome secreted by MSC contain mother cell-specific proteins, lipids and nucleic acids, and acts as signaling molecule, playing an important role in cell communication, thereby altering target cell function. In this review, the biological characteristics of MSC and its exosome, the mechanism of promoting vascular regeneration in patients with ischemic diseases, and the mechanism of hypoxia-inducible factor-1α（HIF-1α） in the vascular ischemia of ischemic diseases are all summarized briefly.
