Familial Lichen Planus.
- Author:
Hyo Hyun AHN
;
Dong Jun KIM
;
Kil Ju LEE
;
Hae Jun SONG
;
Chil Hwan OH
- Publication Type:Original Article
- MeSH:
Biopsy;
Genetic Predisposition to Disease;
Histocompatibility Testing;
Humans;
Lichen Planus*;
Lichens*;
Siblings;
Skin
- From:Korean Journal of Dermatology
1998;36(3):473-476
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Familial lichen planus is an uncommon disease, and there are 104 cases reported in the English literature. Several theories regarding the etiopathogenesis of lichen planus have been proposed. However, immunological mechanisms and genetic susceptibility have been emphasized the most. Several reports showed HLA analysis in lichen planus patients, and recently 2 cases have revealed an increased frequency of DR1 antigen in patients with lichen planus compared to a control group. We observed two brothers with typical skin lesions of lichen planus of almost simultaneous onset. We confirmed lichen planus by skin biopsies in both brothers and analyzed HLA typing. We also observed the occurrence of DR1 antigen in both of them.
