Expression of Transcription Factor SOX4 in Acute Myeloid Leukemia and Its Clinical Significance.
10.7534/j.issn.1009-2137.2019.01.004
- Author:
Jia-Lin ZHAO
1
;
Zheng-Hao ZHANG
1
;
Rui WANG
1
;
Hai-Long YUAN
1
;
Gang CHEN
1
;
Juan ZHANG
1
;
Ma-Li-Ya MUHASHI
1
;
Jian-Hua QU
2
Author Information
1. Center of Blood Diseases, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China.
2. Center of Blood Diseases, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China.E-mail: jhuaqu@163.com.
- Publication Type:Journal Article
- MeSH:
Bone Marrow;
Humans;
Leukemia, Myeloid, Acute;
Leukocyte Count;
Prognosis;
SOXC Transcription Factors;
genetics;
metabolism
- From:
Journal of Experimental Hematology
2019;27(1):20-24
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expression of SOX4 gene in patients with acute myeloid leukemia (AML) and its correlation with clinical features and prognosis, and to explore the role of this gene in acute myeloid leukemia.
METHODS:The real-time guantitative PCR was used to detect the expression level of SOX4 gene in bone marrow of 96 patients with newby diagmsed AML, and the features and prognosis was analyzed.
RESULTS:The level of SOX4 expression in the 96 AML patients was significantly higher than that in healthy controls (P<0.01), and the expression of SOX4 gene was not significanly different between M1-M5 (P<0.05). The expression of SOX4 gene was no significanly different between different sex, nationality, and remission after chemotherapy (P>0.05). In AML patients the SOX4 gene expression level did not significantly correlated with the white blood cell count, hemoglobin level, platelet count primitive cell count, reticulocyte count and other laboratory indexes ( P>0.05), while which correlated with the overall survival (OS) (P<0.01) and erent-free survival (EFS) (P<0.05).
CONCLUSION:The high expression of SOX4 gene affects the survival time of patients (OS, EFS), suggesting that may be one of the unfavorable prognostic factors for the AML patients.
