Emerging role of Mitochondria in Maintenance of Hematopoietic Stem Cells--Review.
10.7534/j.issn.1009-2137.2019.01.045
- Author:
Zi-Xian LIU
1
;
Fang DONG
1
;
Sen ZHANG
1
;
Ming-Zhe HAN
1
;
Hideo EMA
2
Author Information
1. State Key Laboratory of Experimental Hematology，Institute of Hematology & Blood Diseases Hospital，Chinese Academy of Medical Sciences & Peking Union Medical College，Tianjin 300020，China.
2. State Key Laboratory of Experimental Hematology，Institute of Hematology & Blood Diseases Hospital，Chinese Academy of Medical Sciences & Peking Union Medical College，Tianjin 300020，China.E-mail: hema@ihcams.ac.cn.
- Publication Type:Journal Article
- MeSH:
Cell Differentiation;
Hematopoiesis;
Hematopoietic Stem Cells;
Mitochondria;
Oxidative Stress
- From:
Journal of Experimental Hematology
2019;27(1):277-282
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondria are double-membrane organelles existing only in eukaryotic cells. Mitochondria perform various important functions，such as producing energy，regulating signal transduction，and contributing to stress response. Recent studies have highlighted an important role of mitochondria in the determination of hematopoietic stem cells （HSC） fate. Limited biogenesis or timely clearance of mitochondria is an important way against oxidative stress，which favors the quiescence of HSC. Accumulation of mitochondria may lead to proliferation of HSC，even the aging of HSC. Mitochondrial signaling regulates Ca concentration，which is essential for HSC differentiation. This review summarizes the current findings of the mitochondrial roles in HSC quiescence，self-renewal，lineage differentiation and aging.
