Research Advances on Role of Extracellular Vesicles in the Bone Marrow Microenvironment of Patients with Hematological Malignancies--Review.
10.7534/j.issn.1009-2137.2019.01.047
- Author:
Cheng-Ming FEI
1
;
Chun-Kang CHANG
2
Author Information
1. Department of Hematology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China.
2. Department of Hematology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China.E-mail: changchunkang7010@aliyun.com.
- Publication Type:Journal Article
- MeSH:
Bone Marrow;
Cell Communication;
Extracellular Vesicles;
Hematologic Neoplasms;
Humans
- From:
Journal of Experimental Hematology
2019;27(1):288-291
- CountryChina
- Language:Chinese
-
Abstract:
Bone marrow (BM) microenvironment appears to play an important role in the pathogenesis of hematological malignancies. Apart from soluble factors and direct cell-cell contact, the extracellular vesicles (EVs) were identified as a third mediator for cell communication within BM microenvironment. Recently, more and more evidences have demonstrated that EVs are also involved in the dysregulation of the BM microenvironment in patients with hematological malignancies. Therefore this review focuses on the biological characteristics of EVs, the clinical value of EVs as biomarkers, the BM microenvironment reprogramming in hematological malignancies by EVs, and the potential role of EVs in drug resistance and therapy of hematological malignancies.
