Research Advances of Monocyte/Macrophage in Chronic Lymphocytic Leukemia--Review.
10.7534/j.issn.1009-2137.2019.01.048
- Author:
Xiao-Wen MA
1
;
Lin-Hua YANG
2
Author Information
1. Department of Hematology, The Second Affiliated Hospital of Shanxi Medical University, Taiyuan 031001, Shanxi Province, China.
2. Department of Hematology, The Second Affiliated Hospital of Shanxi Medical University, Taiyuan 031001, Shanxi Province, China.E-mail: yanglh5282@163.com.
- Publication Type:Journal Article
- MeSH:
Humans;
Leukemia, Lymphocytic, Chronic, B-Cell;
Macrophages;
Monocytes;
Tumor Microenvironment
- From:
Journal of Experimental Hematology
2019;27(1):292-296
- CountryChina
- Language:Chinese
-
Abstract:
Chronic lymphocytic leukemia（CLL）is a malignant hematologic disease with heterogeneous clinical course, about two thirds of patients exhibit a long survival, but the remaining third of patients show aggressiveness of disease or poor response to conventional treatment even drug resistance. Studies suggested that tumor microenvironment possesses a critical effect in CLL disease progression in recent years. Monocyte/macrophage, as an important componens of tumor microenvironment, play a promotive role in the growth and drug reistance of tumor cells by direct cell-to-cell contact, secreting cytokines and suppressing antitumor responses. Therefore, exploring the monocyte/macrophage in CLL can provide theoretic basis for target treatment of CLL. In this review, the function of monocyte/macrophage and recent advances in therapy of CLL are discussed.
