Epi-Leptosphaerin: A New L-Isoascorbic Acid Derivative from Marine Sponges.
10.20307/nps.2015.21.4.293
- Author:
Roshan R KULKARNI
1
;
A Reum JO
;
Young Ho KIM
;
MinKyun NA
Author Information
1. College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea. mkna@cnu.ac.kr
- Publication Type:Original Article
- Keywords:
L-isoascorbic acid;
soluble epoxide hydrolase;
Verongida sponges
- MeSH:
Comorbidity;
Inflammation;
Inhibitory Concentration 50;
Porifera*
- From:Natural Product Sciences
2015;21(4):293-296
- CountryRepublic of Korea
- Language:English
-
Abstract:
A new L-isoascorbic acid derivative epi-leptosphaerin (1) and two known compounds leptosphaerin (2), and verongamine (3) were isolated from sponges of the orders Verongida and Thorectidae. Compounds 1 and 2 are most likely of sponge-associated fungal origin. In the present study, isolated compounds were investigated for their inhibition of soluble epoxide hydrolase (sEH), which is considered a promising target for the management of pain, inflammation, and comorbidities associated with diabetes. Compound 3, verongamine, displayed weak inhibitory activity against sEH with an IC50 value 51.5 +/- 1.0 microM.
