Neuromodulatory effects of ethyl acetate fraction of Zingiber officinale Roscoe extract in rats with lead-induced oxidative stress.
10.1016/j.joim.2019.01.002
- Author:
Mary Abiola OKESOLA
1
;
Basiru Olaitan AJIBOYE
2
;
Babatunji Emmanuel OYINLOYE
2
;
Oluwafemi Adeleke OJO
3
,
4
Author Information
1. Department of Biochemistry, Covenant University, Ogun State 112233, Nigeria. Electronic address: oluwafemiadeleke08@gmail.com.
2. Department of Biochemistry, Afe Babalola University, Ado-Ekiti 360001, Nigeria.
3. Department of Biochemistry, Afe Babalola University, Ado-Ekiti 360001, Nigeria
4. Department of Biochemistry, University of Ilorin, Ilorin 240003, Nigeria.
- Publication Type:Journal Article
- Keywords:
Acetylcholinesterase;
Lead acetate;
Monoamine oxidase;
Na(+)/K(+)-ATPase;
Neurodegenerative disorders;
Zingiber officinale
- From:
Journal of Integrative Medicine
2019;17(2):125-131
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:This study investigated the ameliorative potential of Zingiber officinale Roscoe extract against lead-induced brain damage in rats.
METHODS:Thirty male rats were divided into 5 groups of 6 rats each. Lead-acetate toxicity was induced by intraperitoneal injection (10 mg/kg body weight (b.w.)) in Groups B-E. Group A (control) and Group B (lead-acetate) were left untreated; vitamin C (200 mg/kg b.w.) was administered to Group C; ethyl acetate fraction from Z. officinale extract (200 and 100 mg/kg b.w.) was administered to Group D and E by oral gavage once daily for 7 days. Changes in the content of some key marker enzymes such as acetylcholinesterase (AChE), butyrylcholinesterase (BChE), monoamine oxidase (MAO), epinephrine, dopamine, Na/K-ATPase, catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) as well as malonaldehyde (MDA) levels were determined in serum.
RESULTS:Exposure to lead acetate resulted in a significant decrease (P < 0.05) in the activities of BChE, AChE, Na/K-ATPase, SOD, CAT and GPx with a corresponding increase in the levels of MDA, xanthine oxidase, epinephrine, dopamine and MAO relative to the control group. Levels of all disrupted parameters were alleviated by co-administration of Z. officinale fraction and by the standard drug, vitamin C.
CONCLUSION:These results suggest that ethyl acetate fraction of Z. officinale extract attenuates lead-induced brain damage and might have therapeutic potential as a supplement that can be applied in lead poisoning.
