Hemodynamic analysis of a new retrievable vena cava filter.
10.7507/1001-5515.201808032
- Author:
Siyuan CHEN
1
;
Haiquan FENG
2
;
Xiaoqiang LI
3
;
Jianping GU
4
;
Xiaotian WANG
5
;
Ping CAO
6
;
Yonggang WANG
7
Author Information
1. College of Mechanical Engineering, Inner Mongolia University of Technology, Hohhot 010000, P.R.China.
2. College of Mechanical Engineering, Inner Mongolia University of Technology, Hohhot 010000, P.R.China.fhq515@163.com.
3. Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210000, P.R.China.
4. Nanjing Hospital Affiliated to Nanjing Medical University, Nanjing 210006, P.R.China.
5. The First Affiliated Hospital of University of Science and Technology of China, Hefei 230000, P.R.China.
6. Shenzhen Medical Device Testing Center, Shenzhen, Guangdong 518057, P.R.China.
7. Suzhou Venmed Technology Co., Ltd, Suzhou, Jiangsu 215000, P.R.China.
- Publication Type:Journal Article
- Keywords:
hemodynamics;
pulmonary embolism;
thrombus capture efficiency;
vena cava filters;
wall shear stress
- MeSH:
Blood Flow Velocity;
Hemodynamics;
Humans;
Software;
Thrombosis;
therapy;
Vena Cava Filters;
Vena Cava, Inferior
- From:
Journal of Biomedical Engineering
2019;36(2):245-253
- CountryChina
- Language:Chinese
-
Abstract:
Vena cava filter is a filter device designed to prevent pulmonary embolism caused by thrombus detached from lower limbs and pelvis. A new retrievable vena cava filter was designed in this study. To evaluate hemodynamic performance and thrombus capture efficiency after transplanting vena cava filter, numerical simulation of computational fluid dynamics was used to simulate hemodynamics and compare it with the commercialized Denali and Aegisy filters, and in vitro experimental test was performed to compare the thrombus capture effect. In this paper, the two-phase flow model of computational fluid dynamics software was used to analyze the outlet blood flow velocity, inlet-outlet pressure difference, wall shear stress on the wall of the filter, the area ratio of the high and low wall shear stress area and thrombus capture efficiency when the thrombus diameter was 5 mm, 10 mm, 15 mm and thrombus content was 10%, 20%, 30%, respectively. Meanwhile, the thrombus capture effects of the above three filters were also compared and evaluated by in vitro experimental data. The results showed that the Denali filter has minimal interference to blood flow after implantation, but has the worst capture effect on 5 mm small diameter thrombus; the Aegisy filter has the best effect on the trapping of thrombus with different diameters and concentrations, but the low wall shear stress area ratio is the largest; the new filter designed in this study has a good filtering and capture efficiency on small-diameter thrombus, and the area ratio of low wall shear stress which is prone to thrombosis is small. The low wall shear stress area of the Denali and Aegisy filters is relatively large, and the risk of thrombosis is high. Based on the above results, it is expected that the new vena cava filter designed in this paper can provide a reference for the design and clinical selection of new filters.
