Research progress on signaling molecules involved in articular cartilage repair.
10.7507/1001-5515.201806021
- Author:
Pengcheng TU
1
;
Yang GUO
2
,
3
;
Suyang ZHENG
1
;
Yalan PAN
1
;
Lining WANG
1
;
Yong MA
2
,
3
Author Information
1. Nanjing University of Chinese Medicine, Nanjing 210023, P.R.China.
2. Nanjing University of Chinese Medicine, Nanjing 210023, P.R.China
3. Department of Traumatology & Orthopedics, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, P.R.China.
- Publication Type:Journal Article
- Keywords:
articular cartilage;
cartilage repair;
signaling molecules;
signaling pathway;
tissue engineering
- MeSH:
Bone Morphogenetic Proteins;
physiology;
Cartilage, Articular;
growth & development;
injuries;
Chondrocytes;
physiology;
Humans;
Regeneration;
Signal Transduction;
Transforming Growth Factor beta;
physiology
- From:
Journal of Biomedical Engineering
2019;36(2):343-348
- CountryChina
- Language:Chinese
-
Abstract:
After the articular cartilage injury, the metabolic level is increased during the progressive degeneration, the chondrocytes secrete a variety of inflammatory factors, and the original cell phenotype is gradually changed. For a long time, a large number of researchers have done a lot of researches to promote anabolism of chondrocytes and to maintain the stability of chondrocyte phenotype. There are many molecular signaling pathways involved in the process of promoting cartilage repair. This review focuses on the key signaling molecules in articular cartilage repair, such as transforming growth factor-beta and bone morphogenetic protein, and reveals their roles in the process of cartilage injury and repair, so that researchers in related fields can understand the molecular mechanism of cartilage injury and repair widely and deeply. Based on this, they may find promising targets and biological methods for the treatment of cartilage injury.
