Coagulation function and hemorrhagic diseases in preterm infants with different gestational ages.
- Author:
Liang GAO
1
;
Xin-Zhu LIN
;
Qian-Qian WU
;
Yu-Cong LIN
;
Kun-Yao HONG
Author Information
1. Department of Neonatology, Xiamen Maternal and Child Health Care Hospital, Xiamen, Fujian 361000, China. gaoliang811@163.com.
- Publication Type:Journal Article
- MeSH:
Blood Coagulation;
Blood Coagulation Tests;
Gestational Age;
Humans;
Infant, Newborn;
Partial Thromboplastin Time;
Prothrombin Time
- From:
Chinese Journal of Contemporary Pediatrics
2019;21(2):120-124
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the correlation between coagulation function and gestational age in preterm infants and the possible value of coagulation function measurement in predicting hemorrhagic diseases.
METHODS:The clinical data of preterm infants who were hospitalized between September 2016 and August 2017 were collected. The coagulation indicators were measured within 2 hours after birth. According to the gestational age, the preterm infants were divided into late preterm infant group (n=322), early preterm infant group (n=241) and extremely/very early preterm infant group (n=128). Coagulation function was compared among the three groups, as well as between the preterm infants with and without hemorrhagic diseases within 3 days after birth.
RESULTS:There were significant differences in thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen degradation product (FDP) and D-dimer (DD) among the three groups (P<0.05). APTT, PT, FDP and DD were negatively correlated with gestational age, while TT was positively correlated with gestational age (P<0.05). The preterm infants with hemorrhagic diseases had a longer APTT and a higher level of DD (P<0.05).
CONCLUSIONS:Coagulation function gradually becomes mature in preterm infants with the increase in gestational age. Abnormal APTT and DD indicate that preterm infants may have a higher risk of hemorrhagic diseases.
