Value of galactose-deficient IgA1 in the early diagnosis of Henoch-Schönlein purpura nephritis in children.
- Author:
Zhi-Juan KANG
1
;
Bo LIU
;
Zhi-Hui LI
;
Cui-Rong DUAN
;
Tian-Hui WU
;
Man XUN
;
Yi ZHANG
;
Yun-Feng DING
;
Ru-Qian FU
Author Information
1. Department of Nephrology and Rheumatology, Hunan Children's Hospital/Academy of Pediatrics of University of South China, Changsha 410007, China. Lizh0731@aliyun.com.
- Publication Type:Journal Article
- MeSH:
Child;
Early Diagnosis;
Galactose;
Glomerulonephritis, IGA;
Humans;
Immunoglobulin A;
Purpura, Schoenlein-Henoch
- From:
Chinese Journal of Contemporary Pediatrics
2019;21(2):172-175
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the value of galactose-deficient IgA1 (Gd-IgA1) in the early diagnosis of Henoch-Schönlein purpura nephritis (HSPN) in children.
METHODS:A total of 67 hospitalized children who were definitely diagnosed with HSPN between January and April 2018 and 58 hospitalized children with Henoch-Schönlein purpura (HSP) were enrolled in the study. Twenty children undergoing routine physical examinations served as controls. The levels of serum and urine Gd-IgA1 were determined using ELISA. The receiver operating characteristic curve was used to analyze the value of serum Gd-IgA1 and urine Gd-IgA1/urine creatinine ratio in the diagnosis of HSPN.
RESULTS:The level of serum Gd-IgA1 and urine Gd-IgA1/urine creatinine ratio in children with HSP or HSPN were significantly higher than those in healthy control group (P<0.01), with a significantly greater increase observed in children with HSPN (P<0.01). Serum Gd-IgA1 ≥1 485.57 U/mL and/or urine Gd-IgA1/urine creatinine ratio ≥105.74 were of favorable value in the diagnosis of HSPN. During the six-month follow-up of the 49 children with HSP, the incidence of HSPN was 47% (23/49), which included a 100% incidence in children with serum Gd-IgA1 ≥1 485.57 U/mL and a 73% incidence in children with urine Gd-IgA1/urine creatinine ratio ≥105.74.
CONCLUSIONS:Serum and urine Gd-IgA1 is of favorable clinical value in the early diagnosis of HSPN.
