Serum metabolomics of preterm and full-term infants based on gas chromatography-mass spectrometry.
- Author:
Fu-Sheng WANG
1
;
Wei-Zhong LI
;
Guang-Huan WANG
;
Meng-Lu YU
;
Jun ZHONG
;
Chen-Bin XU
;
Dan-Li LI
;
Yong-Cui ZHOU
Author Information
1. Department of Pediatric Surgery, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, China. zycwgh@126.com.
- Publication Type:Journal Article
- MeSH:
Gas Chromatography-Mass Spectrometry;
Humans;
Infant, Newborn;
Infant, Premature;
Metabolic Networks and Pathways;
Metabolome;
Metabolomics
- From:
Chinese Journal of Contemporary Pediatrics
2019;21(3):259-264
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the features of serum metabolites in preterm infants based on gas chromatography-mass spectrometry (GC-MS), and to find differentially expressed metabolites in the serum of preterm infants.
METHODS:Serum samples were collected from 19 preterm infants and 20 full-term infants before feeding. GC-MS was used to measure metabolic profiles, and the metabolic features of 397 serum metabolites in preterm infants were analyzed.
RESULTS:There was a significant difference in serum metabolic features between the preterm and full-term infants before feeding. There were significant differences between the full-term and preterm infants in the levels of metabolites such as O-phosphonothreonine, digicitrin, tannic acid, and fructose-1,6-diphosphate (P<0.01), suggesting that the above differentially expressed metabolites were highly differentiated between the preterm and full-term infants. Most differentially expressed metabolites were involved in the metabolic pathways such as ABC transporters, β-alanine and pyrimidines and were correlated with some clinical parameters (albumin and total bilirubin) (P<0.05).
CONCLUSIONS:There is a significant difference in serum metabolites between preterm and full-term infants before feeding. Metabolomics plays an important role in improving metabolic disorders and exploring metabolism-related diseases in preterm infants.
