Clinical features of cow's milk protein allergy in infants presenting mainly with gastrointestinal symptoms: an analysis of 280 cases.
- Author:
Qing-Hua YANG
1
;
Bing-Sheng ZHENG
;
Shao-Ming ZHOU
;
Dong-Ling DAI
Author Information
1. Department of Gastroenterology, Shenzhen Children's Hospital, Shantou University Medical College, Shenzhen, Guangdong 518036, China. daidong3529@sina.com.
- Publication Type:Journal Article
- MeSH:
Animals;
Breast Feeding;
Cattle;
Female;
Humans;
Infant;
Milk Hypersensitivity;
Milk Proteins;
Retrospective Studies
- From:
Chinese Journal of Contemporary Pediatrics
2019;21(3):271-276
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the epidemiological and clinical features of cow's milk protein allergy (CMPA) in infants presenting mainly with gastrointestinal symptoms.
METHODS:A retrospective analysis was performed for the clinical data of 280 hospitalized infants, who were diagnosed with CMPA presenting mainly with gastrointestinal symptoms.
RESULTS:Among the 280 infants, 203 infants(72.5%) were aged of less than 6 months. Major manifestations included diarrhea in 171 infants (61.1%), hematochezia in 149 infants (53.2%), vomiting in 71 infants (25.4%), eczema in 57 infants (20.4%), malnutrition in 42 infants (15%) and constipation in 13 infants (4.6%). Of the 280 infants, 258 (92.1%) had mild-to-moderate CMPA and 22 (7.9%) had severe CMPA. Compared with the mild-to-moderate CMPA group, the severe CMPA group had a significantly higher incidence rate of malnutrition (50.0% vs 12.0%) and a significantly lower incidence rate of hematochezia (22.7% vs 55.8%). The breastfeeding CMPA group had significantly lower incidence rates of malnutrition (10.3% vs 24.6%) and severe CMPA (4.4% vs 18.0%) than the artificial feeding CMPA group, and the artificial feeding CMPA group had a significantly lower incidence rate of hematochezia than the breastfeeding and mixed feeding CMPA groups (37.7% vs 56.6%/59.0%).
CONCLUSIONS:CMPA presenting mainly with gastrointestinal symptoms is more common in infants aged of less than 6 months. Diarrhea and hematochezia are the most common manifestations at the time of onset. Most infants have mild-to-moderate allergy. Compared with breastfeeding, artificial feeding is more likely to cause malnutrition and severe CMPA.
