Expression and significance of dishevelled proteins in the Wnt pathway in childhood acute lymphoblastic leukemia.
- Author:
Wen-Peng WANG
1
;
Lei GUO
;
Yan LI
;
Li-Hui LU
;
Ying CHANG
;
Bi ZHOU
;
Min ZHOU
;
Xuan LI
;
Ji-Zhao GAO
Author Information
1. Department of Pediatric Hematology and Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, China. xz3765595@163.com.
- Publication Type:Journal Article
- MeSH:
Child;
Dishevelled Proteins;
Humans;
Phosphoproteins;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
Wnt Signaling Pathway
- From:
Chinese Journal of Contemporary Pediatrics
2019;21(5):411-414
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the significance of dishevelled (DVL) proteins in the Wnt signaling pathway in the pathogenesis and prognosis of childhood acute lymphoblastic leukemia (ALL).
METHODS:A total of 33 children with new-onset ALL were enrolled as the case group. According to the degree of risk, they were divided into 3 groups: low-risk (n=14), intermediate-risk (n=5) and high-risk (n=14). A total of 29 children with immune thrombocytopenia were enrolled as the control group. At diagnosis and on day 33 of induction therapy, 2 mL bone marrow samples were collected from the case and control groups, and qRT-PCR was used to measure the mRNA expression of DVL1, DVL2 and DVL3 in blood cells of bone marrow.
RESULTS:The mRNA expression of DVL1, DVL2 and DVL3 in the case group in the incipient stage was significantly higher than that in the remission stage and the control group (P<0.05). Compared with the control group, the case group had a significant increase in the mRNA expression of DVL2 in the remission stage (P<0.05). The mRNA expression of DVL2 was significantly higher than that of DVL1 and DVL3 in both remission and incipient stages (P<0.05). The high- and intermediate-risk groups had significantly higher mRNA expression of DVL1 and DVL2 than the low-risk group (P<0.05). The mRNA expression of DVL2 was significantly higher than that of DVL1 and DVL3 in the low-, intermediate- and high-risk groups (P<0.05).
CONCLUSIONS:The change in the expression of DVL, especially DVL2, in the Wnt signal pathway has certain significance in the pathogenesis and prognosis of childhood ALL.
