Clinical value of serum neuroglobin in evaluating hypoglycemic brain injury in neonates.
- Author:
Feng-Yuan JIANG
1
;
Hui-Ping LIU
;
Li-Ting CHEN
;
Zhong-Rui SONG
;
Shang XU
;
Yu-Xiu GUO
;
Lin ZHOU
;
Yu-Kun WANG
;
Gui-Hua SHU
Author Information
1. Department of Pediatrics, Yizheng Hospital, Drum Tower Hospital Group of Nanjing, Yizheng, Jiangsu 211900, China. yzsbsgh@126.com.
- Publication Type:Journal Article
- MeSH:
Brain Injuries;
Electroencephalography;
Humans;
Hypoglycemic Agents;
Infant, Newborn;
Neuroglobin;
blood;
Phosphopyruvate Hydratase
- From:
Chinese Journal of Contemporary Pediatrics
2019;21(6):573-579
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the clinical value of serum neuroglobin in evaluating hypoglycemic brain injury in neonates.
METHODS:A total of 100 neonates with hypoglycemia were enrolled as subjects. According to amplitude-integrated EEG (aEEG) findings and/or clinical manifestations, they were divided into symptomatic hypoglycemic brain injury group (n=22), asymptomatic hypoglycemic brain injury group (n=37) and hypoglycemic non-brain injury group (n=41). The three groups were compared in terms of blood glucose, duration of hypoglycemia, levels of neuroglobin and neuron-specific enolase (NSE), and modified aEEG score. The correlation of neuroglobin with NSE and modified aEEG score was analyzed. The receiver operating characteristic (ROC) curve was plotted.
RESULTS:Compared with the asymptomatic hypoglycemic brain injury and hypoglycemic non-brain injury groups, the symptomatic hypoglycemic brain injury group had significantly lower blood glucose and modified aEEG score, significantly higher neuroglobin and NSE levels, and a significantly longer duration of hypoglycemia (P<0.05). Compared with the hypoglycemic non-brain injury group, the asymptomatic hypoglycemic brain injury group had significantly lower blood glucose and modified aEEG score, significantly higher neuroglobin and NSE levels, and a significantly longer duration of hypoglycemia (P<0.05). Neuroglobin was positively correlated with NSE and duration of hypoglycemia (r=0.922 and 0.929 respectively; P<0.05) and negatively correlated with blood glucose and modified aEEG score (r=-0.849 and -0.968 respectively; P<0.05). The areas under the ROC curve of neuroglobin, NSE and modified aEEG score were 0.894, 0.890 and 0.941 respectively, and neuroglobin had a sensitivity of 80.8% and a specificity of 95.8% at the optimal cut-off value of 108 mg/L.
CONCLUSIONS:Like NSE and modified aEEG score, serum neuroglobin can also be used as a specific indicator for the assessment of brain injury in neonates with hypoglycemia and has a certain value in clinical practice.
