Distribution of Telocytes in Vital Organs of ApoE Mice.
10.3881/j.issn.1000-503X.10520
- Author:
Ying XU
1
;
Hu TIAN
1
;
Jian YU
1
;
Jia Lin CHENG
2
;
Yu Cheng ZHAO
2
Author Information
1. Department of General Surgery,Shandong University Affiliated Shandong Provincial Qianfoshan Hospital,Jinan 250014,China.
2. Graduate School of Tai Shan Medical College,Tai'an,Shandong 271000,China.
- Publication Type:Journal Article
- MeSH:
Animals;
Antigens, CD34;
metabolism;
CD28 Antigens;
metabolism;
Kidney;
cytology;
Liver;
cytology;
Mice;
Mice, Knockout, ApoE;
Myocardium;
cytology;
Proto-Oncogene Proteins c-kit;
metabolism;
Telocytes;
cytology
- From:
Acta Academiae Medicinae Sinicae
2018;40(6):778-784
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify and verify the distribution of Telocytes derived from heterogeneous interstitial cells in the vital organs of ApoE mice.Methods Heart,kidney,and liver tissues were harvested from ApoE adult mice. Immunohistochemical assays were performed by using different immunobiological markers.Results Telocytes were found in these vital organs. The expressions of immunobiological markers differed among different organs. CD34,CD117,and CD28 were positively expressed in Telocytes in cardiac tissue;CD117 and plateled-derived growth factor-Α were negatively expressed in Telocytes in renal tissue;and CD117 and plateled-derived growth factor receptor-Α had negative expression in Telocytes in hepatic tissue. Furthermore,the distribution of Telocytes also differed in the same organ.Conclusions Telocytes exist in the vital organs of ApoE mice,as demonstrated by immunohistochemisty assay. The expressions of immunobiological markers differ among Telocytes in different organs.
