Research Advances in Exosomes in Chronic Airway Inflammatory Disease.
10.3881/j.issn.1000-503X.10301
- Author:
Chao LIU
1
;
Jun WANG
2
Author Information
1. Department of Medicine,Graduate School of Nanchang University,Nanchang 330006,China.
2. Second Department of Respiratory Medicine,Jiangxi Provincial People's Hospital,Nanchang 330006,China.
- Publication Type:Journal Article
- MeSH:
Asthma;
physiopathology;
Biomarkers;
Exosomes;
Humans;
MicroRNAs;
Pulmonary Disease, Chronic Obstructive;
physiopathology;
RNA, Messenger
- From:
Acta Academiae Medicinae Sinicae
2018;40(6):832-837
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are 40 - 100 nm vesicular bodies that are formed by the fusion of the multi-vesicular bodies and the plasma membrane and can be released into the extracellular space by a variety of cells through exocytosis. With rich active genetic substances such as proteins,mRNAs,and microRNAs,exosomes can exert their biological functions by transferring cargos to the recipient cells. In recent years,the roles of exosomes in oncology have been rapidly recognized. Some of them have been investigated in phase I trials. Preliminary studies have demonstrated that exosomes play important roles in the physiological and pathological processes of chronic inflammatory airway diseases such as bronchial asthma and chronic obstructive pulmonary disease. Meanwhile,exosomes may serve as useful biomarkers in the diagnosis and treatment of chronic inflammatory airway diseases.
