Clinical observation of iron sucrose combined with recombinant human erythropoietin in the treatment of anemia of hip fracture in elderly patients.
10.3969/j.issn.1003-0034.2019.05.011
- Author:
Hong-Yao XU
1
;
Zhi-Hong DAI
1
;
He HUANG
2
,
3
Author Information
1. Nanjing Hospital Affiliated to Nanjing Medical University, Nanjing First Hospital, Nanjing 210006, Jiangsu, China.
2. Nanjing Hospital Affiliated to Nanjing Medical University, Nanjing First Hospital, Nanjing 210006, Jiangsu, China
3. 342482410@qq.com.
- Publication Type:Journal Article
- Keywords:
Erythropoietin;
Hip fractures;
Iron sucrose
- MeSH:
Aged;
Anemia;
Erythropoietin;
Ferric Oxide, Saccharated;
Hemoglobins;
Hip Fractures;
Humans;
Recombinant Proteins
- From:
China Journal of Orthopaedics and Traumatology
2019;32(5):444-447
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the clinical efficacy of iron sucrose combined with recombinant human erythropoietin(EPO) for the treatment of anemia in elderly patients with hip fracture.
METHODS:From February 2016 to April 2018, 96 elderly anemia patients who underwent hip fracture surgery were divided into three groups according to the treatment methods. All the three groups received anti-anemia treatment 3 days before operation. Among them, 32 cases in group A were treated with iron sucrose alone, 32 cases in group B were treated with recombinant human erythropoietin alone, and 32 cases in group C were treated with iron sucrose combined with recombinant human erythropoietin. The therapeutic effects of the three groups were observed and compared.
RESULTS:The clinical effective rate in group C was significantly higher than that in group A and B (<0.05). There was no significant difference in perioperative blood loss among the three groups(>0.05), but the transfusion rate in group C was significantly lower than that in group A and B (<0.05). There was no significant difference in hemoglobin and erythrocyte counts among the three groups before treatment(>0.05), but the above indexes in group C were significantly higher than those in group A and B(<0.05) at 1, 3 and 5 days after operation. There was no significant difference in the incidence of adverse drug reactions among the three groups(>0.05).
CONCLUSIONS:Compared with single drug, the combined use of sucrose and iron and recombinant human erythropoietin in the treatment of elderly hip fracture anemia has a definite effect. It can not only effectively improve the level of hemoglobin, ensure the smooth operation, but also reduce the blood transfusion rate of patients and promote their recovery after operation.
