Changes of some biochemical markers and cardiac function in New Zealand rabbits with chronic heart failure.
10.12047/j.cjap.5534.2018.019
- Author:
Ben-Mei ZHOU
1
;
Xing-Ming GUO
1
;
Yi-Neng ZHENG
1
;
Hong-Quan LI
1
Author Information
1. College of Bioengineering, Chongqing University, Chongqing Engineering Research Center for Medical Electronic Technology, Chongqing 400044, China.
- Publication Type:Journal Article
- Keywords:
New Zealand rabbits;
cardiac function;
cardiac reserve index;
chronic heart failure
- MeSH:
Animals;
Biomarkers;
analysis;
Blood Pressure;
Carotid Arteries;
physiopathology;
Chronic Disease;
Doxorubicin;
Electrocardiography;
Heart Failure;
chemically induced;
physiopathology;
Myocardium;
enzymology;
Phonocardiography;
Rabbits;
Random Allocation
- From:
Chinese Journal of Applied Physiology
2018;34(1):74-77
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:This article investigated the changes of some biochemical markers and cardiac function in chronic heart failure (CHF), and provided the basis for the diagnosis of CHF.
METHODS:New Zealand rabbit CHF model was established using adriamycin (ADR). Twenty New Zealand rabbits were randomly divided into model group (=15) and control group (=5), injected with ADR and saline solution the ear vein respectively, 2 times a week, lasting for 8 weeks. After that, myocardial enzymes, carotid artery pressure, echocardiogram (ECG) and phonocardiogram (PCG) of all New Zealand rabbits were detected and recorded.
RESULTS:Compared with control group, all parameters of the model group were changed significantly (<0.05).
CONCLUSIONS:CHF leads to myocardial damage in New Zealand rabbits, decreased systolic and diastolic function, cardiac reserve index can be used to assess cardiac function.
