Research Related to Chronic Kidney Disease in BMI >25 Overweight Children.
- Author:
Ah Reum CHOI
1
;
Sung Sin PARK
;
Sung Do KIM
;
Byoung Soo CHO
Author Information
1. Department of Pediatrics, Colleage of Medicine, Kyunghee University, Seoul, Korea. bscho@dreamwiz.com
- Publication Type:Original Article
- Keywords:
BMI;
Chronic kidney disease (CKD);
Laboratory data;
Result of kidney biopsy
- MeSH:
Biopsy;
Blood Platelets;
Child;
Glomerulonephritis, Membranoproliferative;
Hematuria;
Humans;
Incidence;
Kidney;
Nephritis;
Obesity;
Overweight;
Public Health;
Renal Insufficiency, Chronic;
Risk Factors;
Uric Acid
- From:Journal of the Korean Society of Pediatric Nephrology
2009;13(1):75-83
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Chronic kidney disease (CKD) and obesity are the worldwide public health problem. Obesity is an already well-established risk factor for CKD. The objective of this study is to evaluate the relationship between high BMI and increased risk for nephropathy by clinical data. METHODS: Study group were 26 patients who had BMI> or =25 kg/m2 and control group were 49 patients with BMI<25 kg/m2. Both groups received renal biopsy in Kyung Hee Medical Center between 2003. Jan.-2007. Dec. BMI was calculated from measured weight and height when they were admitted to the hospital. We collected laboratory data such as CBC and blood chemistry. RESULTS: Our hypothesis was that overweight and obesity are associated with incidence and progression of CKD. From kidney biopsy, we found IgAN 17, MesPGN 5, HSPN 2, Intestitial nephritis 1, IgMN 1 (total 26) in the study group whereas IgAN 22, MesPGN 17, HSPN 3, MGN 3, benign hematuria 2, MPGN 1, Intestitial nephritis 1, (total 49) were found in the control group. There was no significant difference between the two groups. Overweight patients demonstrated significantly higher platelet, TG, ALT, and uric acid level compared to control group. CONCLUSION: We identified a significant relationship between overweight and development of CKD. These results suggest that overweight children have an increased risk for CKD than those who are not obese. So, we should pay attention to children with overweight who have CKD and earlier weight management is crucial to prevent aggravation of CKD.
