Research thoughts and methods on grading identification and transmission change law of traditional Chinese medicine(TCM) Q-marker.
10.19540/j.cnki.cjcmm.20190408.201
- Author:
Yu-Ping TANG
1
;
Er-Xin SHANG
2
;
Yan-Yan CHEN
1
;
Shi-Jun YUE
1
;
Jie YANG
1
;
Sai ZHANG
1
;
Jia-Jia LI
1
;
Jin-Ao DUAN
2
Author Information
1. Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility,and State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation) ,Shaanxi University of Chinese Medicine Xi'an 712046,China.
2. Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,Nanjing University of Chinese Medicine Nanjing 210023,China.
- Publication Type:Journal Article
- Keywords:
TCM Q-maker;
TCM quality control;
functional components;
grading identification;
transmission and traceability
- MeSH:
Biomarkers;
Drugs, Chinese Herbal;
standards;
Medicine, Chinese Traditional;
standards;
Quality Control
- From:
China Journal of Chinese Materia Medica
2019;44(14):3116-3122
- CountryChina
- Language:Chinese
-
Abstract:
The quality marker( Q-maker) of traditional Chinese medicine( TCM) has been the core concept of TCM quality evaluation and control in recent years. Based on the knowledge and long-term practice of the researches on TCM quality,we put forward that " Taking the effectiveness as the core,the measurability and peculiarity as necessary conditions,and considering compatibility for TCM formulae,TCM Q-makers are selected and confirmed,and then the transmission and traceability should be investigated as its functional attributes". Selecting the commonly used representative TCM as the research object,based on the score of TCM effectiveness,measurability and peculiarity,a layered three-dimensional integrated technology was adopted for the quantitative evaluation and grading identification of the Q-markers for TCM. And after Q-markers for TCM are selected and confirmed,the transmission variation of the Q-markers is studied in the whole process from the formation of TCM to its function representation. Based on TCM chemical and biological characteristics as well as effectiveness,and integrating multidisciplinary techniques and methods,researches on innovative methods for system identification and confirmation of the TCM Q-makers are developed emphatically to form representative and exemplary extensive application,which will provide significant theoretical and methodological support for effectively improving the quality control level of TCM.
