Traditional Chinese medicine (tumor) prevention and evaluation model based on ultra-early immune response information amplification index naCTL and multidimensional immunoinformatic index TCR/BCR/HLA effective diversity.
10.19540/j.cnki.cjcmm.20190522.502
- Author:
Yi-Guan ZHANG
1
;
Jun-Ning ZHAO
1
Author Information
1. Sichuan Center for Translational Medicine of Traditional Chinese Medicine,Institute of Translational Pharmacology of Sichuan Academy of Chinese Medicine Sciences,State Key Laboratory of Quality Evaluation of Traditional Chinese Medicine,Sichuan Geoherbs System Engineering Technology Research Center of Chinese Medicine,Sichuan Provincial Key Laboratory of Quality Evaluation of Traditional Chinese Medicine and Innovative Chinese Medicine Research Chengdu 610041,China.
- Publication Type:Journal Article
- Keywords:
immune repertoire;
naCTL;
normalization of immunity;
principle of treatment for strengthening healthy Qi to elimin ate pathogens;
treating weibing Chinese medicine(tumor) funnel evaluation
- MeSH:
Drugs, Chinese Herbal;
HLA Antigens;
Humans;
Medicine, Chinese Traditional;
Neoplasms;
immunology;
prevention & control;
Receptors, Antigen, B-Cell;
Receptors, Antigen, T-Cell
- From:
China Journal of Chinese Materia Medica
2019;44(15):3129-3134
- CountryChina
- Language:Chinese
-
Abstract:
The best time of tumor intervention is before the formation of tumor. However,due to the limited number of tumor cells,it is difficult to quantify tumor cells and immunity by the current methods available( such as CTC,ct DNA). This affects the tumor prevention in this period,and the in-depth detection,intervention and evaluation of traditional Chinese medicine( TCM)( tumor) prevention. Due to the limitations of the current detection,the evaluation system turns to detect tumor neoantigen-specific CTL( naCTL) that are directly relating to tumor cells and proliferate to high order of magnitudes after activation,and immune repertoire( TCR/BCR/HLA) effective diversity,introduces immune checkpoints,uses information of " disease" in Western medicine and " syndrome" in TCM( prevention),and sets up a multi-dimensional statistical immunity model using a variety of data analysis and related algorithms. This model can amplify the ultra-early information of tumor,indirectly evaluate the quantity and status of tumor cells,and provide quantitative measurement and new evaluation methods for the normalization of immunity and TCM( tumor) prevention. This model is not only one of important evaluation methods for resisting tumor immunity and treating TCM( tumor) prevention,but also will reveal the scientific connotation of TCM syndrome from the perspective of immunology.
