Discussion on research thought of dry granulation of traditional Chinese medicine: research progress at home and abroad based on dry granulation technology.
10.19540/j.cnki.cjcmm.20190523.303
- Author:
Wan-Wan KUANG
1
;
Zhen-Feng WU
2
;
Na WAN
1
;
Yuan-Hui LI
1
;
Xue-Cheng WANG
1
;
Chao-Chao KANG
1
;
Zhen-Feng LIU
3
;
Ming YANG
1
Author Information
1. State Key Laboratory of Innovation Drug and Efficient Energy-saving Pharmaceutical Equipment,Jiangxi University of Traditional Chinese Medicine Nanchang 330004,China.
2. State Key Laboratory of Innovation Drug and Efficient Energy-saving Pharmaceutical Equipment,Jiangxi University of Traditional Chinese Medicine Nanchang 330004,China Yichun Wanshen Pharmaceutical Machinery Co.,Ltd. Yichun 336000,China.
3. Yichun Wanshen Pharmaceutical Machinery Co.,Ltd. Yichun 336000,China.
- Publication Type:Journal Article
- Keywords:
Chinese medicine;
dry granulation technology;
on-line detection and prediction model;
quality evaluation;
research ideas
- MeSH:
Desiccation;
Drugs, Chinese Herbal;
Medicine, Chinese Traditional;
Models, Theoretical;
Powders;
Quality Control;
Technology, Pharmaceutical
- From:
China Journal of Chinese Materia Medica
2019;44(15):3195-3202
- CountryChina
- Language:Chinese
-
Abstract:
Dry granulation technology is a great innovation in granulation technology,which saves many intermediate links and reduces many intermediate costs. It is closely related to the characteristics of materials,dry granulation equipment and process. Dry granulation technology is a systematic engineering science covering many technical fields. The process of dry granulation involves complex mathematical model mechanisms of temperature field,pressure field and velocity field,closely related to the characteristics of materials and drying equipment. However,due to the late start of research on dry granulation technology of traditional Chinese medicine,basic research is still weak. The research on dry granulation technology has achieved great results in the fields of food,chemical industry,agriculture and forestry,showing great reference significance. The advantage of dry granulation of traditional Chinese medicine is that it can be directly granulated by adding an appropriate amount of auxiliary materials in the extract powder of traditional Chinese medicine,without the need of wetting,mixing,drying and other processes. The process is simple and can effectively guarantee the quality of traditional Chinese medicine. The granules obtained by the dry granulation technique are important intermediates for preparing the solid preparations of traditional Chinese medicines,which would directly affect the subsequent molding process and the quality of the preparation products. Therefore,based on the characteristics of dry granulation method in traditional Chinese medicine and by referring to the advanced research results of dry granulation technology in other fields,we would discuss the research ideas of dry granulation in traditional Chinese medicine in terms of the mechanism of dry granulation equipment,technology,on-line detection technology and mathematical model of dry granulation process,hoping to provide reference for the research of dry granulation method in traditional Chinese medicine.
