Progress of effect and mechanisms of Tripterygium wilfordii on immune system.
10.19540/j.cnki.cjcmm.20190419.401
- Author:
Cheng NONG
1
;
Xin-Zhi WANG
2
;
Zhen-Zhou JIANG
1
;
Lu-Yong ZHANG
3
Author Information
1. Jiangsu Key Laboratory of Drug Screening,China Pharmaceutical University Nanjing 210009,China.
2. Jiangsu Key Laboratory of Drug Screening,China Pharmaceutical University Nanjing 210009,China Jiangsu Center for Pharmacodynamics Research and Evaluation,China Pharmaceutical University Nanjing 210009,China.
3. Jiangsu Key Laboratory of Drug Screening,China Pharmaceutical University Nanjing 210009,China Center for Drug Research and Development,Guangdong Pharmaceutical University Guangzhou 510006,China.
- Publication Type:Journal Article
- Keywords:
Tripterygium wilfordii;
immune;
mechanisms
- MeSH:
Arthritis, Rheumatoid;
drug therapy;
Drugs, Chinese Herbal;
pharmacology;
Humans;
Immune System;
drug effects;
Plant Extracts;
pharmacology;
Tripterygium;
chemistry
- From:
China Journal of Chinese Materia Medica
2019;44(16):3374-3383
- CountryChina
- Language:Chinese
-
Abstract:
Traditional Chinese medicine Tripterygium wilfordii Hook.f( TWHF) is a natural botanical drug in China. It has complex chemical compositions and has been used for a long history. TWHF was used as an insecticide to protect crops at early stage,and it was later found to have significant effects in the treatment of rheumatoid arthritis,attaining great concerns. With further researches,it was found that TWHF can treat various diseases in the medical field due to a variety of pharmacological activities such as anti-cancer,neuroprotection,anti-inflammatory and immune-suppressing,particularly. Multiple extracts of TWHF have unique immunosuppressive function,playing an immune role through multi-target and multi-channel,with significant effect in the treatment of autoimmune diseases. As an immune-suppressing drug,TWHF is worthy of in-depth research due to its broad application prospects. While achieving good clinical efficacy,reports about its toxic effects to multiple systems of the body are also increasing,greatly hindering its clinical application. In order to fully understand the immune-suppressing function of TWHF and reduce or avoid the occurrence of toxic and side effects,we summarized recent progress of TWHF on the immune organs,cells and factors in recent years,as well as the pharmacology and toxic effects,hoping to provide a scientific and reasonable reference for its wider use in clinical treatment.
