Study advances in regulation effect of Tripterygium wilfordii and its extracts on innate immune system in rheumatoid arthritis cases.
10.19540/j.cnki.cjcmm.20190103.001
- Author:
Jian-Ming LI
1
;
Quan JIANG
1
;
Xiao-Po TANG
1
;
Hui YANG
1
;
Zhi-Qiang ZHOU
1
Author Information
1. Guang'anmen Hospital,China Academy of Chinese Medical Sciences Beijing 100053,China.
- Publication Type:Journal Article
- Keywords:
Tripterygium glycosides;
Tripterygium wilfordii;
celastrol;
innate immunity;
pathogenesis;
rheumatoid arthritis;
triptolide
- MeSH:
Arthritis, Rheumatoid;
drug therapy;
Drugs, Chinese Herbal;
therapeutic use;
Humans;
Immunity, Innate;
Plant Extracts;
therapeutic use;
Tripterygium;
chemistry
- From:
China Journal of Chinese Materia Medica
2019;44(16):3384-3390
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis( RA) is an autoimmune disease characterized by chronic and aggressive polyarthritis. The innate immunity mechanism plays a key role in the pathogenesis of RA. Tripterygium wilfordii and its extracts have regulatory effects on innate immune cells including macrophages,dendritic cells,neutrophils,mast cells,NK cells,NKT cells,etc.,as well as a variety of innate immune molecules including cytokines,adhesion molecules,patterns recognition receptor( PRR) and the complement molecules,showing a regulatory effect in the pathogenesis of RA innate immunity. In this paper,the recent domestic and foreign researches on the pathogenesis of RA with innate immunity involved were reviewed and the research status of T. wilfordii and its extracts on the regulation of innate immunity involved in RA was summarized.
