Research progress on anti-tumor effects and mechanisms of triptolide and its combined application.
10.19540/j.cnki.cjcmm.20190610.402
- Author:
Jin-Feng SHI
1
;
Yao-Yao LUO
1
;
Jia-Xin LI
1
;
Rui-Feng LUO
1
;
Liang CHEN
1
;
Jie LI
1
;
Jin-Ming ZHANG
1
;
Chao-Mei FU
1
Author Information
1. Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine,Key Laboratory of Systematic Research,Development and Utilization of Chinese Medicine Resources in Sichuan Province-State Key Laboratory Breeding Base Co-founded by Sichuan Province and MOST,College of Pharmacy,Chengdu University of Traditional Chinese Medicine Chengdu 611137,China.
- Publication Type:Journal Article
- Keywords:
anti-tumor effects;
combined application;
mechanism;
triptolide
- MeSH:
Antineoplastic Agents, Phytogenic;
pharmacology;
Apoptosis;
Autophagy;
Cell Cycle Checkpoints;
Diterpenes;
pharmacology;
Epoxy Compounds;
pharmacology;
Humans;
Neoplasms;
drug therapy;
Phenanthrenes;
pharmacology;
Tripterygium;
chemistry
- From:
China Journal of Chinese Materia Medica
2019;44(16):3391-3398
- CountryChina
- Language:Chinese
-
Abstract:
Tumors are major chronic diseases and seriously threaten human health all over the world. How to effectively control and cure tumors is one of the most pivotal problems in the medical field. At present,surgery,radiotherapy and chemotherapy are still the main treatment methods. However,the side effects of radiotherapy and chemotherapy cannot be underestimated. Therefore,it is of great practical significance to find new anti-cancer drugs with low toxicity,high efficiency and targeting to cancer cells. With the increasing incidence of tumor,the anti-tumor effect of traditional Chinese medicine has increasingly become a research hotspot. Triptolide,which is a natural diterpenoid active ingredient derived from of Tripterygium wilfordii,as one of the highly active components,has anti-inflammatory,immunosuppressive,anti-tumor and other multiple effects. A large number of studies have confirmed that it has good anti-tumor activity against various tumors in vivo and in vitro. It can play an anti-tumor role by inhibiting the proliferation of cancer cells,inducing apoptosis of cancer cells,inducing autophagy of cancer cells,blocking the cell cycle,inhibiting the migration,invasion and metastasis of cancer cells,reversing multidrug resistance,mediating tumor immunity and inhibiting angiogenesis. On the basis of literatures,this paper reviews the anti-tumor effect and mechanism of triptolide,and analyzes the current situation of triptolide combined with other chemotherapy drugs,in order to promote deep research and better clinical application about triptolide.
