Bioinformatics analysis on immune response pathways of triptolide in treating AIDS.
10.19540/j.cnki.cjcmm.20190702.401
- Author:
Li LI
1
;
Xiao-Juan HE
1
;
Chi ZHANG
1
;
Ning ZHAO
1
;
Cheng LYU
1
Author Information
1. Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences Beijing 100700,China.
- Publication Type:Journal Article
- Keywords:
AIDS(acquired immune deficiency syndrome);
immune response;
triptolide
- MeSH:
Acquired Immunodeficiency Syndrome;
drug therapy;
immunology;
Computational Biology;
Diterpenes;
pharmacology;
Epoxy Compounds;
pharmacology;
Gene Regulatory Networks;
Humans;
Interferon-gamma;
genetics;
Phenanthrenes;
pharmacology;
Receptors, Pattern Recognition;
immunology;
Signal Transduction;
T-Lymphocytes;
immunology
- From:
China Journal of Chinese Materia Medica
2019;44(16):3448-3453
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this paper was to study the influence of triptolide in the immune response pathways of acquired immune deficiency syndrome( AIDS). Target proteins of triptolide and related genes of AIDS were searched in PubChem and Gene databases on line. Molecular networks and canonical pathways comparison analyses were performed by bioinformatics software( IPA). There were 15 targets proteins of triptolide and 258 related genes of AIDS. Close biological relationships of molecules of triptolide and AIDS were established by networks analysis. There were 21 common immune response pathways of triptolide and AIDS,including neuroinflammation signaling pathway,Th1 and Th2 activation pathway and role of pattern recognition receptors in recognition of bacteria and viruses. Triptolide stimulated immune response pathways by the main molecules of IFNγ,JAK2,NOD1,PTGS2,RORC. IFNγ is the focus nodes of triptolide and AIDS,and regulates genes of AIDS directly or indirectly. Triptolide may against AIDS by regulating molecules IFNγ in immune response pathways.
