Pharmacodynamic effect and virulent effect of Tripterygium wilfordii based on network pharmacology.
10.19540/j.cnki.cjcmm.20181119.001
- Author:
Yi-Zhu DONG
1
;
Bing ZHANG
2
;
Zhi-Jian LIN
1
;
Xiao-Meng ZHANG
1
Author Information
1. School of Chinese Pharmacy,Beijing University of Chinese Medicine Beijing 100029,China.
2. School of Chinese Pharmacy,Beijing University of Chinese Medicine Beijing 100029,China Center for Pharmacovigilance and Rational Use of Chinese Medicine,Beijing University of Chinese Medicine Beijing 100029,China.
- Publication Type:Journal Article
- Keywords:
ADME/T;
Tripterygium wilfordii;
network pharmacology;
pharmacodynamics;
toxicity
- MeSH:
Computational Biology;
Drugs, Chinese Herbal;
pharmacology;
Humans;
Inflammation;
Signal Transduction;
Tripterygium;
chemistry
- From:
China Journal of Chinese Materia Medica
2019;44(16):3460-3467
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the pharmacodynamic effect and virulent effect of the main components of the toxic Chinese medicine Tripterygium wilfordii,such as triptolide,tripchlorolide,tripterine,demethylzeylasteral,wilfotrine and euonine,the admet SAR online assessment system was used to calculate the properties of the main components of T. wilfordii. The potential targets of the components were mined and collected through multiple databases,and the potential targets were enriched by the bioinformatics database DAVID.Cytoscape software was used to establish a " target-pathway" network and perform topology analysis on the network. The main chemical components of T. wilfordii were able to penetrate the blood-brain barrier and had intestinal permeability. A total of 65 targets were predicted,including pathways in cancer,hepatitis B,rheumatoid arthritis,and chagas disease( American trypanosomiasis),Toll-like receptor signaling pathway,apoptosis,colorectal cancer,NF-kappa B signaling pathway,etc. T. wilfordii mainly plays a role in the treatment of immune diseases and cancer by regulating inflammatory signaling pathways and cancer signaling pathways. Its action on apoptosis pathway and drug metabolism enzymes may be the mechanism of its toxicity.
