Meta-analysis of laboratory index of Tripterygium Glycosides Tablets in treatment of rheumatoid arthritis.
- Author:
Tai-Xian LI
1
;
Xiao-Yue WANG
1
;
Zhi-Peng XUE
2
;
Cheng LYU
3
;
Hui-Zhen LI
3
;
Yuan-Fang FAN
1
;
Yi-Qun LI
1
;
Ya-Ge TIAN
1
;
Jun YANG
1
;
Wen-Jia CHEN
1
;
Min-Qun GUO
1
;
Jing-Xia WANG
1
;
Hong-Yan WU
1
;
Wei-Heng CHEN
2
;
Yan-Qiong ZHANG
1
;
Na LIN
1
Author Information
- Publication Type:Journal Article
- Keywords: Meta-analysis; Tripterysium Glycosides Tablets; laboratory index; rheumatoid arthritis; systematic review
- MeSH: Antirheumatic Agents; therapeutic use; Arthritis, Rheumatoid; drug therapy; Drug Therapy, Combination; Drugs, Chinese Herbal; therapeutic use; Glycosides; therapeutic use; Humans; Methotrexate; therapeutic use; Randomized Controlled Trials as Topic; Tablets; Treatment Outcome; Tripterygium; chemistry
- From: China Journal of Chinese Materia Medica 2019;44(16):3542-3550
- CountryChina
- Language:Chinese
- Abstract: The aim of this study was to systematically evaluate the clinical efficacy of Tripterysium Glycosides Tablets( TGT) alone or in combination with methotrexate( MTX) in the treatment of rheumatoid arthritis( RA) based on the laboratory index criteria and to provide a basis for the clinical application of TGT against RA. Six databases including CNKI,Wan Fang,VIP,PubMed,EMbase and Cochrane were retrieved for randomized controlled trials( RCT) about TGT alone or combination with MTX in the treatment of RA.Then risk assessment tools were used for quality evaluation of the studies,and data extraction and analysis were conducted by using Rev Man 5.3 software for Meta-analysis. A total of 1 709 articles were retrieved,and finally 25 studies were included,with a total sample size of 2 507 cases. Meta-analysis results showed that between TGT alone and TGT alone,MDESR=-2. 66,95%CI[-8.17,2.86],P = 0.35; MDCRP=-2.38,95%CI[-9.01,4.24],P = 0.48; between TGT combined with MTX and MTX alone,MDESR= 8.74,95%CI[6.72,10.76],P<0.000 01; MDCRP= 5.37,95%CI[3.71,7.03],P<0.000 01; SMDRF= 1.05,95%CI[0.51,1.60],P = 0.000 1.The effect of TGT on decreasing CRP and ESR in RA patients was similar to the MTX. In addition,TGT combined with MTX were more effective in decreasing CRP,ESR,RF than MTX alone. However,due to the potential bias in the included studies,more and high-quality randomized controlled trials would be needed to improve the level of evidence.
