Reviews on natural monocyclic sesquiterpenoids and their bioactivities.
10.19540/j.cnki.cjcmm.20190415.201
- Author:
Jia FU
1
;
Feng-Hua LI
1
;
Chang-Kang LI
1
;
Bao-Ming LI
1
;
Ruo-Yun CHEN
1
;
Jie KANG
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050,China.
- Publication Type:Journal Article
- Keywords:
anti-inflammatory activity;
antioxidative;
cytotoxicity;
monocyclic sesquiterpenes;
neuroprotective activity
- MeSH:
Anti-Bacterial Agents;
pharmacology;
Anti-Inflammatory Agents;
pharmacology;
Antioxidants;
pharmacology;
Molecular Structure;
Sesquiterpenes;
pharmacology
- From:
China Journal of Chinese Materia Medica
2019;44(17):3672-3683
- CountryChina
- Language:Chinese
-
Abstract:
Sesquiterpenes are a class of terpenoids composed of three isoprene units( 15 carbons). Sesquiterpenoids possess a variety of different structures,including acyclic sesquiterpenes,monocyclic sesquiterpenoids,bicyclic sesquiterpenoids,tricyclic sesquiterpenoids,tetracyclic sesquiterpenoids and macrocyclic sesquiterpenoids. Among them,a large number of monocyclic sesquiterpenoids were isolated and display extensive bioactivities,such as cytotoxic,antioxidant,anti-inflammatory,antibacterial and other activities. In this review,we summarized the progress about the phytochemistry and biological activities of monocyclic sesquiterpenoids( a total of161 compounds) reported from 2014 to 2018( 5 years),including megastigmanes,monocyclofarnesol-type,bisabolane-type,germacrane-type,and other types of monocyclic sesquiterpenoids. Furthermore,several future research perspectives and development of sesquiterpenoids as potential therapeutic agents were discussed as well.
