A new isobenzofuranone derivative from Chaenomeles sinensis and its antibacterial activity.
10.19540/j.cnki.cjcmm.20190507.201
- Author:
Yan-Qi SUN
1
;
Ling-Min LIAO
1
;
Xi GAO
2
;
Qi-Li MI
2
;
Hai-Tao HUANG
2
;
Yong XU
2
;
Cheng-Ming ZHANG
2
;
Guang-Yu YANG
2
;
Jian-Gang LI
3
;
Yan-Qing YE
4
Author Information
1. College of Chemical and Environment,Yunnan Minzu University Kunming 650500,China Technology Center,China Tobacco Yunnan Industrial Co.,Ltd. Kunming 650106,China.
2. Technology Center,China Tobacco Yunnan Industrial Co.,Ltd. Kunming 650106,China.
3. Department of Anesthesiology,Qujing First People's Hospital Qujing 655000,China.
4. College of Chemical and Environment,Yunnan Minzu University Kunming 650500,China.
- Publication Type:Journal Article
- Keywords:
Chaenomeles sinensis;
antibacterial activity;
isobenzofuranone
- MeSH:
Anti-Bacterial Agents;
isolation & purification;
pharmacology;
Benzofurans;
isolation & purification;
pharmacology;
Chromatography, High Pressure Liquid;
Methicillin-Resistant Staphylococcus aureus;
drug effects;
Microbial Sensitivity Tests;
Phytochemicals;
isolation & purification;
pharmacology;
Rosaceae;
chemistry
- From:
China Journal of Chinese Materia Medica
2019;44(17):3745-3748
- CountryChina
- Language:Chinese
-
Abstract:
A new isobenzofuranone derivative was isolated from Chaenomeles sinensis by using various chromatographic techniques,including silica gel,Sephadex LH-20,MCI-gel resin and RP-HPLC. This compound was determined as 2,2-dimethyl-5-( 2-oxopropyl)-2 H-furo[3,4-h]chromen-7( 9 H)-one( 1) by NMR,MS,IR and UV spectra,and was also evaluated for its antibacterial activity. The results showed that it showed prominent antibacterial activity with MIC90 value of( 53. 7±4. 5) mg·L-1 for methicillin resistant Staphylococcus aureus( MRSA) strain. This value is close to that of levofloxacin [with MIC90 value( 50. 2± 4. 2) mg·L-1].
