Plasma levels of interferon-inducible protein 10 in patients with active pulmonary tuberculosis with different affected areas.
10.12122/j.issn.1673-4254.2019.05.18
- Author:
Haiping DONG
1
;
Zhihui LIU
1
;
Xiaocheng LIANG
1
;
Yiluan JIAN
1
;
Dexian LI
1
;
Suihua LAO
1
;
Feng LIANG
1
;
Yanshan PAN
1
;
Xiaojia KUANG
1
Author Information
1. Guangzhou Chest Hospital, Guangzhou 510095, China.
- Publication Type:Journal Article
- Keywords:
auxiliary diagnosis;
interferon-inducible protein 10;
pulmonary tuberculosis;
severity of the disease
- MeSH:
Antigens, Bacterial;
Biomarkers;
blood;
Chemokine CXCL10;
blood;
Humans;
Tuberculosis, Pulmonary;
blood;
diagnosis
- From:
Journal of Southern Medical University
2019;39(5):609-613
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the value of interferon-inducible protein 10 (IP-10) in the auxiliary diagnosis of tuberculosis and the judgment of the severity of disease.
METHODS:From February, 2013 to February, 2017, a total of 193 patients with TB admitted in our hospital and 84 healthy control subjects were recruited consecutively. The peripheral blood plasma levels of interferon-γ (IFN-γ) and IP-10 were detected using liquid phase chip (Luminex) technique. According to the number of lung fields affected by TB, the patients were divided into group A (with lesions in 1-2 lung fields), group B (3-4 lung fields) and group C (5-6 lung fields), The expressions of IFN-γ and IP-10 in 3 groups were compared.
RESULTS:The plasma levels of IP-10 were significantly higher in TB patients than in the control subjects ( < 0.05), but IFN-γ levels were comparable between the two groups ( > 0.05). Among the TB patients, plasma IP-10 levels was the highest in group C ( < 0.05), and IFN-γ levels did not differ significantly among the 3 groups ( > 0.05).
CONCLUSIONS:Plasma IP-10 has a certain reference value in the auxiliary diagnosis of active tuberculosis and the judgment of the severity of the disease.
