Role of lipophagy in the regulation of lipid metabolism and the molecular mechanism.
10.12122/j.issn.1673-4254.2019.07.19
- Author:
Linna SHI
1
;
Ke WANG
2
;
Yudi DENG
3
;
Yingna WANG
4
;
Shuangling ZHU
5
;
Xushan YANG
3
;
Wenzhen LIAO
3
Author Information
1. Department of Nutrition, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
2. School of Public Health, Southern Medical University, Guangzhou 510515, China.
3. College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510640, China.
4. Guangzhou Sanxing Biotechnology Co., Ltd., Guangzhou 510000, China.
5. First Affiliated Hospital, Sun Yat- sen University, Guangzhou 510080, China.
- Publication Type:Journal Article
- Keywords:
autophagy;
lipid metabolism;
molecular mechanism
- MeSH:
Adipose Tissue;
Autophagy;
Homeostasis;
Lipid Metabolism;
Liver
- From:
Journal of Southern Medical University
2019;39(7):867-874
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies have discovered a selective autophagy-lipophagy, which can selectively identify and degrade lipids and plays an important role in regulating cellular lipid metabolism and maintaining intracellular lipid homeostasis. The process of lipophagy can be directly or indirectly regulated by genes, enzymes, transcriptional regulators and other factors. This review examines the role of lipophagy in reducing liver lipid content, regulating pancreatic lipid metabolism, and regulating adipose tissue differentiation, and summarizes the findings of the molecules (Rab GTPase, enzymes, ion channels, transcription factors, small molecular substances) involved in the regulation of lipophagy, which points to new directions for the treatment of diseases caused by lipid accumulation.
