Computed tomography findings, clinicopathological features, genetic characteristics and prognosis of and minimally invasive lung adenocarcinomas.
10.12122/j.issn.1673-4254.2019.09.17
- Author:
Leilei SHEN
1
;
Jixing LIN
1
;
Bailin WANG
1
;
Hengliang XU
1
;
Kai ZHAO
1
;
Lianbin ZHANG
1
Author Information
1. Department of Thoracic Surgery, Hainan Hospital of General Hospital of PLA, Sanya 572000, China.
- Publication Type:Journal Article
- Keywords:
gene mutation;
in situ adenocarcinoma;
minimally invasive adenocarcinoma;
survival
- MeSH:
Adenocarcinoma of Lung;
diagnostic imaging;
pathology;
ErbB Receptors;
genetics;
Humans;
Ki-67 Antigen;
genetics;
Lung Neoplasms;
diagnostic imaging;
pathology;
Mutation;
Prognosis;
Retrospective Studies;
Tomography, X-Ray Computed
- From:
Journal of Southern Medical University
2019;39(9):1107-1112
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the computed tomography findings, clinicopathological features, genetic characteristics and prognosis of in situ adenocarcinoma (AIS) and minimally invasive adenocarcinoma (MIA) of the lung.
METHODS:We retrospectively analyzed the data including computed tomography (CT) images, histopathological findings, Ki-67 immunostaining, and genetic mutations in patients with lung adenocarcinoma undergoing surgery at our hospital between 2014 and 2019.
RESULTS:Of the total of 480 patients with lung adenocarcinoma we reviewed, 73 (15.2%) had AIS (=28) or MIA (=45) tumors. The age of the patients with MIA was significantly younger than that of patients with AIS ( < 0.02). CT scans identified pure ground-glass nodules in 46.4% of AIS cases and in 44.4% of MIA cases. Multiple GGOs were more common in MIA than in AIS cases ( < 0.05), and bluured tumor margins was less frequent in AIS cases ( < 0.05). No significant difference was found in EGFR mutations between MIA and AIS cases. A Ki-67 labeling index (LI) value ≥2.8% did not differentiate MIA from AIS. The follow-up time in MIA group was significantly shorter than that in AIS group, but no recurrence or death occurred.
CONCLUSIONS:Despite similar surgical outcomes and favorable survival outcomes, the patients with AIS and MIA show differences in terms of age, CT findings, EGFR mutations and Ki-67 LI.
