Research progress of the role of postoperative pain in the development of postoperative cognitive dysfunction in geriatric patients.
10.12122/j.issn.1673-4254.2019.09.20
- Author:
Xiaohui CHEN
1
;
Xiaoqiang REN
2
;
Yabing MA
1
;
Li GE
1
;
Zhongyuan HU
1
;
Wenjun YAN
1
Author Information
1. Department of Anesthesiology, Gansu Provincial People's Hospital, Lanzhou 730000, China.
2. Department of Orthopedics, Zhangye People's Hospital Affiliated to Hexi University, Zhangye 734000, China.
- Publication Type:Journal Article
- Keywords:
elderly patients;
mechanisms;
postoperative cognitive dysfunction;
postoperative pain;
prevention
- MeSH:
Aged;
Cognitive Dysfunction;
etiology;
Humans;
Inflammation;
Pain, Postoperative;
complications;
therapy;
Postoperative Complications
- From:
Journal of Southern Medical University
2019;39(9):1122-1126
- CountryChina
- Language:Chinese
-
Abstract:
Previous studies have shown that postoperative cognitive dysfunction (POCD) is related to multiple factors including age, postoperative trauma, inflammation, postoperative pain, and anesthesia, among which postoperative pain is thought to play an important role in the development of POCD. This review summarizes the recent findings in the study of the role of postoperative pain in the pathogenesis of POCD in light of nerve injuries, neural remodeling and stress, and the progress in the prevention and treatment of POCD in elderly patients. It is of vital important to assess the postoperative pain and formulate adequate analgesic regimens for effective prevention and management of POCD to protect the brain functions of elderly patients.
