Correlation between serum 25(OH) vitamin D and liver fat content in nonalcoholic fatty liver disease.
10.12122/j.issn.1673-4254.2019.09.19
- Author:
Likun FU
1
;
Hongmei CUI
1
;
Kunling LU
1
;
Chunyan ZOU
1
;
Guixian JI
1
;
Li LI
1
;
Jinglong LI
1
;
Lina SHENG
1
;
Changshun XIE
1
Author Information
1. Department of Gastroenterology, First Hospital of Qinhuangdao, Qinhuangdao 066000, China.
- Publication Type:Journal Article
- Keywords:
liver fat content;
nonalcoholic fatty liver disease;
serum 25 (OH) vitamin D
- MeSH:
Humans;
Liver;
pathology;
Non-alcoholic Fatty Liver Disease;
blood;
pathology;
Vitamin D;
blood
- From:
Journal of Southern Medical University
2019;39(9):1118-1121
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the relationship between serum 25(OH) vitamin D and liver fat content in nonalcoholic fatty liver disease (NAFLD).
METHODS:A total of 120 patients with NAFLD admitted in our hospital between June and August, 2017 were enrolled and divided into 4 groups with different serum 25 (OH) vitamin D levels: >75 nmol/L (group A, =25), 50-75 nmol/L (group B, =35), 25-50 nmol/L (group C, =32), and < 25 nmol/L (group D, =28). For all the patients, serum 25 (OH) vitamin D level was measured by ELISA, and liver fat content was determined using in-phase opposed-phase TWI sequences. The measurement data were compared among the 4 groups to assess the association between serum 25(OH) vitamin D level and liver fat content.
RESULTS:The liver fat content appeared to be higher in group B (28.66±6.45%) and group C (38.74±11.47%) than in group A (22.79 ± 6.10%), but the difference was not statistically significant (>0.05); the liver fat content in group D (54.79 ± 5.28%) was significantly higher than that in the other 3 groups (>0.05). Liver fat content increased significantly as serum 25(OH) vitamin D level decreased, showing an inverse correlation between them in these patients ( < 0.05, =-0.125).
CONCLUSIONS:In patients with NAFLD, a decreased serum 25(OH) vitamin D level is associated with an increased liver fat content, suggesting the value of serum 25(OH) vitamin D as a predictor of NAFLD.
