Ideal Cardiovascular Health is Inversely Associated with Subclinical Atherosclerosis: A Prospective Analysis.
- Author:
Long WANG
1
;
Jing Ya NIU
1
;
Zhi Yun ZHAO
1
;
Mian LI
1
;
Min XU
1
;
Jie Li LU
1
;
Tian Ge WANG
1
;
Yu Hong CHEN
1
;
Shuang Yuan WANG
1
;
Meng DAI
1
;
Lin LI
1
;
Shan Shan LIU
1
;
Wei Qing WANG
1
;
Yu XU
1
;
Yu Fang BI
1
Author Information
- Publication Type:Journal Article
- Keywords: Cardiovascular health; Cohort; Subclinical atherosclerosis
- MeSH: Aged; Atherosclerosis; epidemiology; China; epidemiology; Cross-Sectional Studies; Female; Health Status; Humans; Male; Middle Aged; Prospective Studies
- From: Biomedical and Environmental Sciences 2019;32(4):260-271
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:Ideal cardiovascular health (CVH) could predict a lower risk of developing cardiovascular diseases. This study was conducted to investigate the association between ideal CVH and subclinical atherosclerosis in a population cohort of Chinese adults aged ⪖ 40 years.
METHODS:This study was designed as a cross-sectional analysis of 8,395 participants who had complete data at baseline and a prospective analysis of 4,879 participants who had complete data at 4.3 years of follow-up. Ideal CVH metrics were defined according to the American Heart Association. Subclinical atherosclerosis was evaluated by plaques in carotid arteries, carotid intima-media thickness (CIMT), brachial-ankle pulse wave velocity (baPWV), and urinary albumin-to-creatinine ratio (UACR).
RESULTS:Both the prevalence and incidence of atherosclerosis measures were found to be decreased with increasing numbers of ideal CVH metrics at baseline (all P values for trend < 0.01). The levels of CIMT and UACR at follow-up showed an inverse and significant association with the numbers of ideal CVH metrics at baseline (both P values for trend < 0.05) but a borderline significant association with baPWV (P for trend = 0.0505). Taking participants with 0-1 ideal metric as reference, we found that participants with 5-6 ideal metrics had significantly lower risks of developing carotid plaques (odds ratio, OR = 0.46; 95% confidence interval, CI 0.27-0.79), increased CIMT (OR = 0.60; 95% CI 0.42-0.84), and increased baPWV (OR = 0.57; 95% CI 0.34-0.97) after full adjustments. A significant interactive effect of age and CVH was detected on CIMT and baPWV progression (both P values for interaction < 0.05).
CONCLUSION:The numbers of ideal CVH metrics showed a significant and inverse association with the risk of developing subclinical atherosclerosis in middle-aged and elderly Chinese adults, whereas its dose-response effect was attenuated in individuals aged ≥ 60 years and partially weakened in male participants.
