Association between Lipoprotein (a) Levels and Metabolic Syndrome in a Middle-aged and Elderly Chinese Cohort.

Xue Yan WU; Lin Lin; Hong Yan QI; Rui DU; Chun Yan HU; Li Na MA; Kui Peng; Mian LI; Yu XU; Min XU; Yu Hong Chen; Jie Li LU; Yu Fang BI; Wei Qing Wang; Guang Ning

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Association between Lipoprotein (a) Levels and Metabolic Syndrome in a Middle-aged and Elderly Chinese Cohort.

Author: Xue Yan WU ¹ ; Lin LIN ² ; Hong Yan QI ¹ ; Rui DU ¹ ; Chun Yan HU ¹ ; Li Na MA ¹ ; Kui PENG ¹ ; Mian LI ¹ ; Yu XU ¹ ; Min XU ¹ ; Yu Hong CHEN ² ; Jie Li LU ¹ ; Yu Fang BI ¹ ; Wei Qing WANG ¹ ; Guang NING ¹
Author Information

1. Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai 200025, China.
2. Department of Endocrine and Metabolic Diseases, Rui Jin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Publication Type:Journal Article
Keywords: Cardiovascular risk factor; Lipoprotein (a); Metabolic syndrome
MeSH: Aged; Asian Continental Ancestry Group; China; epidemiology; Cross-Sectional Studies; Female; Humans; Lipoprotein(a); blood; Male; Metabolic Syndrome; blood; epidemiology; Middle Aged
From: Biomedical and Environmental Sciences 2019;32(7):477-485
CountryChina
Language:English
Abstract: OBJECTIVE:The association between lipoprotein (a) [Lp(a)] levels and metabolic syndrome (MetS) remains uncertain, especially in the Asian population. The purpose of this study was to demonstrate the association between Lp(a) levels and MetS in a middle-aged and elderly Chinese cohort.
METHODS:A cross-sectional study of 10,336 Chinese adults aged 40 years or older was conducted in Jiading District, Shanghai, China. Logistic regression analysis was used to evaluate the association between serum Lp(a) levels and MetS.
RESULTS:In the overall population, 37.5% of participants had MetS. Compared with individuals in the lowest quartile of serum Lp(a) levels, those in the highest quartile had a lower prevalence of MetS (30.9% vs. 46.9%, P for trend < 0.0001). Multivariate logistic regression analyses showed that compared with participants in the bottom quartile of serum Lp(a) levels, those in the top quartile had decreased odds ratio (OR) for prevalent MetS [multivariate-adjusted OR 0.45 (95% confidence interval 0.39-0.51); P < 0.0001]. Additionally, Lp(a) level was conversely associated with the risk of central obesity, high fasting glucose, high triglycerides, and low HDL cholesterol, but not with hypertension. Stratified analyses suggested that increasing levels of Lp(a) was associated with decreased risk of MetS in all the subgroups.
CONCLUSION:Serum Lp(a) level was inversely associated with the risk of prevalent MetS in a middle-aged and elderly Chinese cohort.