The Effects of Platelet-Derived Growth Factor and Epidermal Growth Factor on the Periodontal Tissue Regeneration.
10.5051/jkape.1997.27.3.647
- Author:
Jong Woo CHOI
1
;
Man Sup LEE
;
Young Hyuk KWON
;
Joon Bong PARK
;
Yeek HERR
;
Sang Cheol LIM
Author Information
1. Department of Periodontology, College of Dentistry, Kyung Hee University, Korea.
- Publication Type:Original Article
- MeSH:
Animals;
Ankylosis;
Bicuspid;
Dogs;
Epidermal Growth Factor*;
Furcation Defects;
Osteogenesis;
Platelet-Derived Growth Factor*;
Regeneration*;
Tolonium Chloride
- From:The Journal of the Korean Academy of Periodontology
1997;27(3):647-668
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
6 beagle dogs aged over one and half years and weighed 14 to 16 Kg were utilized in this study. Horizontal furcation defects were induced around 2nd, 3rd, and 4th premolars bilaterally. PDGF-BB in conjunction with EGF and PDGF-BB only were applied in the right and left premolars respectively. 2 animals were sacrificed at 4weeks, 8 weeks, and 12 weeks, after regenerative surgery respectively. Semi-thin sections using glass-knife were stained with toluidine blue for light microscopic study. The results were as follows: 1. At 4 weeks after regenerative surgery, bone formation in the PDGF-BB-applied site was thriving, but bone formation in the PDGF-BB-and-EGF-applied site was depressed. 2. Bony ankylosis was surely shown along the whole exposed root surface applied with PDGFBB, but it was shown at the root surface near the base of the bone defect where was applied with PDGF-BB in conjunction with EGF. 3. Active bone formation was made from 8 weeks after regenerative surgery in the PDGFBB-and-EGF-applied site. 4. Bone maturity as well as speed of bone formation in the PDGF-BB-applied site was superior to those in the PDGF-BB-and-EGF-applied site throughout the whole experimental period. Within the above results, PDGF-BB had the strong capability to form the new bone and EGF was not able to prevent the bony ankylosis thoroughly. However, EGF may have the possibility to prevent the bony ankylosis through the suppression of bone formation.
