Consensus on the detection of microsatellite instability in colorectal cancer and other related solid tumors in China.
10.3760/cma.j.issn.0253-3766.2019.10.003
- Author:
Committee of Colorectal Cancer, Chinese Society of Clinical Oncology
;
Genetics Group of The Committee of Colorectal Cancer, China Anti-Cancer Association
;
Genetics Committee of The Committee of Colorectal Cancer, Chinese Medical Doctor Association
- Collective Name:Genetics Committee of The Committee of Colorectal Cancer, Chinese Medical Doctor Association
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Immunohistochemistry;
Microsatellite instability;
Next generation sequencing
- MeSH:
Antineoplastic Agents;
administration & dosage;
adverse effects;
therapeutic use;
China;
Colorectal Neoplasms;
genetics;
pathology;
Consensus;
DNA Mismatch Repair;
DNA Sequence, Unstable;
Delivery of Health Care;
standards;
Endometrial Neoplasms;
Female;
Humans;
Immunohistochemistry;
Microsatellite Instability;
Microsatellite Repeats;
Microscopy, Fluorescence;
Polymerase Chain Reaction;
Practice Guidelines as Topic
- From:
Chinese Journal of Oncology
2019;41(10):734-741
- CountryChina
- Language:Chinese
-
Abstract:
Microsatellite instability (MSI) which resulted from the deficiency of DNA mismatch repair (MMR), is an important clinical significance in the related solid tumors, such as colorectal cancer and endometrial cancer. There are several methods to detect MSI status, including immunohistochemistry for MMR protein, multiplex fluorescent polymerase chain reaction (PCR) for microsatellite site and MSI algorithm based on next generation sequencing (NGS). The consensus elaborates the definition and clinical significance of MSI as well as the advantages and disadvantages of the three detection methods. Through this expert consensus, we hope to promote the screening which based on MSI status in malignant tumors and improve the acknowledge of clinicians about various testing methods. Thereby, they could interpret the results more accurately and provide better clinical services to patients.
