Screening of nucleic acid aptamer of lung cancer cells based on cell exponential enrichment ligand system evolution and its application in tumor diagnosis and treatment.

Author: Jinling XU ¹ ; Shiqi LIAO ¹ ; Caiping TIAN ¹ ; Lei ZHANG ¹ ; Meng ZHAI ¹ ; Congying CHEN ¹ ; Jinzhou TANG ¹ ; Jiayu ZENG ¹
Author Information

1. Department of Biochemistry and Molecular Biology, College of Life Sciences of Northwest Normal University, Lanzhou 730070, P.R.China.
Publication Type:Journal Article
Keywords: aptamer; lung cancer cells; systematic evolution of ligands for cell exponential enrichment technology; tumor diagnosis and treatment
From: Journal of Biomedical Engineering 2018;35(6):964-969
CountryChina
Language:Chinese
Abstract: Nucleic acid aptamer is an oligonucleotide sequence screened by the exponential enrichment ligand system evolution technology (SELEX). Previous studies have shown that nucleic acid aptamer has a good application prospect in tumor diagnosis and treatment. Therefore, we reviewed the selection and identification of nucleic acid aptamer of lung cancer cells in recent years, and discussed the effect of aptamer as targeting drugs and targeting vectors on the diagnosis of tumors, which provide a new idea for early diagnosis and treatment of tumor.