Progress on neurogenesis mechanisms of endogenous adult neural stem cells.

Author: Yibo YING ¹ ; Min CHEN ¹ ; Juanjuan ZHU ¹ ; Guangheng XIANG ¹ ; Mengji CHEN ¹ ; Yiwen MAO ¹ ; Ziqi CHEN ¹ ; Sipin ZHU ¹
Author Information

1. The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R.China.
Publication Type:Journal Article
Keywords: differentiation; migration; molecular mechanisms; neural stem cells; neurogenesis
From: Journal of Biomedical Engineering 2018;35(6):986-992
CountryChina
Language:Chinese
Abstract: Endogenous adult neural stem cells are closely related to the normal physiological functions of the brain and many neurodegenerative diseases. Neurons are affected by factors such as extracellular microenvironment and intracellular signaling. In recent years, some specific signaling pathways have been found that affect the occurrence of neural stem cells in adult neural networks, including proliferation, differentiation, maturation, migration, and integration with host functions. In this paper, we summarize the signals and their molecular mechanisms, including the related signaling pathways, neurotrophic factors, neurotransmitters, intracellular transcription factors and epigenetic regulation of neuronal differentiation from both the extracellular and intracellular aspects, providing basic theoretical support for the treatment of central nervous system diseases through neural stem cells approach.