Association between the dental caries and the human leucocyte antigen DQB1 allele polymorphisms among the Uygur and Han children in Xinjiang.

Zhang Ruihan; Li Xiaobing; Wang Liping; Liu Yishan

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Association between the dental caries and the human leucocyte antigen DQB1 allele polymorphisms among the Uygur and Han children in Xinjiang.

Author: Zhang RUIHAN ¹ ; Li XIAOBING ² ; Wang LIPING ¹ ; Liu YISHAN ¹
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1. Dept. of Pediatric Dentistry & Oral Prevention and Health Care, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Publication Type:Journal Article
Keywords: early childhood caries; genetic polymorphism; human leucocyte antigen
MeSH: Alleles; Asian Continental Ancestry Group; Child; China; Dental Caries; ethnology; genetics; Gene Frequency; Genetic Predisposition to Disease; HLA-DQ beta-Chains; genetics; Humans; Polymerase Chain Reaction; Polymorphism, Genetic
From: West China Journal of Stomatology 2018;36(1):4-8
CountryChina
Language:Chinese
Abstract: OBJECTIVE:This study aims to investigate the association between human leucocyte antigen (HLA)-DQB1 allele polymorphisms and the presence dental caries among the Uygur and Han children in Xinjiang.
METHODS:HLA-DQB1 allele in the Uygur and Han children with dental caries and healthy control in Xinjiang was tested (n=40) using the polymerase chain reaction-sequence specific primer (PCR-SSP) DNA parting technology.
RESULTS:A total of five specific loci were detected in the HLA-DQB1 locus among the Uygur and Han children. The frequency of the HLA-DQB1*02 allele in the Han group with severe caries (12.5%) was significantly lower than in the control group (32.5%) (P<0.05, OR=0.297). Moreover, the frequency of the HLA-DQB1*05 allele in the Uygur group with severe caries (37.5%) was significantly higher than in the control group (17.5%) (P<0.05, OR=2.829).
CONCLUSIONS:Caries susceptibility among the Uygur and Han children in Xinjiang is related to the HLA-DQB1 allele. The HLA-DQB1*02 allele may protect against caries among the Han children, whereas the HLA-DQB1*05 allele may be responsible for the susceptibility of the Uygur children to caries.