Expression and clinical significance of proline-rich tyrosine kinase 2 and phospho-protein kinase B in tongue squamous cell carcinoma.
- Author:
Li LINGLING
1
;
Wang SHENGZHI
1
;
Liu XUYANG
1
;
Liu HAO
1
;
Gong ZHAOHUA
1
Author Information
- Publication Type:Journal Article
- Keywords: phospho-protein kinase B; proline-rich tyrosine kinase 2; tongue squamous cell carcinoma
- MeSH: Carcinoma, Squamous Cell; metabolism; Focal Adhesion Kinase 2; metabolism; Humans; Prognosis; Proto-Oncogene Proteins c-akt; metabolism; Tongue Neoplasms; metabolism
- From: West China Journal of Stomatology 2018;36(1):29-32
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:This study aimed to investigate the expression and clinical significance of proline-rich tyrosine kinase 2 (Pyk2) and phospho-protein kinase B (p-AKT) in tongue squamous cell carcinoma (TSCC) and adjacent nontumor tissues.
METHODS:The Pyk2 and p-AKT protein levels were detected via immunohistochemistry in 45 cases of TSCC tissues and 30 cases of adjacent nontumor tissues. The relationships of the two protein levels and clinicopathological characteristics were also analyzed.
RESULTS:Pyk2 and p-AKT levels were significantly higher in the TSCC tissues than in the adjacent nontumor tissues (P<0.05). Nontumor tissues showed poor or no expression. The expression levels of the two proteins were positively correlated (γs=0.412). The expression of Pyk2 was associated with histopathological differentiation type, regional lymph node metastasis, and TNM staging (P<0.05), but not with age and gender. The expression of p-AKT was only related to histopathological differentiation types (P<0.05).
CONCLUSIONS:The abnormal expression of Pyk2 and p-AKT proteins might be closely related to the development and progression of TSCC. Joint detection can be used as an indicator to estimate the degree of TSCC.
